The anticoagulant effect of warfarin and other coumarins may very well be Improved by extended typical usage of paracetamol with enhanced hazard of bleeding; occasional doses don't have any sizeable effect.與其它鴉片類藥物一樣，可待因的其中一個潛在的嚴重不良反應是壓抑呼吸，通常與服用過量有關，可引致死
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